Journal: PLoS ONE

Article Title: Multistep Ion Channel Remodeling and Lethal Arrhythmia Precede Heart Failure in a Mouse Model of Inherited Dilated Cardiomyopathy

doi: 10.1371/journal.pone.0035353

Figure Lengend Snippet: A . Kaplan-Meier survival curves for DCM mice (n = 211) and their % death in our laboratory. B & C . HW/BW ratio ( B ) and LW/BW ratio ( C ) in WT (n = 5–7) and DCM mice (n = 7 for 1 and 2 months; n = 14 for 3 months). ** P <0.01 between WT and DCM. D . Average wheel running activity of WT and DCM mice at 2 and 3 months. Data at 2 and 3 months were obtained from the same animals (n = 7). * P <0.05 between 2 and 3 months. E . A typical normal ECG trace in WT (a) and representative traces of PVCs (b, c) and T-wave alternans (d) obtained in conscious DCM mice at 2 months. Arrows in b and c indicate premature ventricular contractions (PVCs) occurred before atrioventricular conduction. Dots and arrowheads in d indicate beat-to-beat alteration in T-waves.

Article Snippet: Electrocardiography (ECG) lead II was recorded from mice anesthetized with an intraperitoneal injection (i.p.) of pentobarbital (20–25 mg/kg) using ECG Amplifier (Nihon Koden, Japan).

Techniques: Activity Assay

Journal: PLoS ONE

Article Title: Multistep Ion Channel Remodeling and Lethal Arrhythmia Precede Heart Failure in a Mouse Model of Inherited Dilated Cardiomyopathy

doi: 10.1371/journal.pone.0035353

Figure Lengend Snippet: Summary of in vivo parameters.

Article Snippet: Electrocardiography (ECG) lead II was recorded from mice anesthetized with an intraperitoneal injection (i.p.) of pentobarbital (20–25 mg/kg) using ECG Amplifier (Nihon Koden, Japan).

Techniques: In Vivo

Journal:

Article Title: Role of late sodium current in modulating the proarrhythmic and antiarrhythmic effects of quinidine

doi: 10.1016/j.hrthm.2008.09.008

Figure Lengend Snippet: Representative records of concentration-dependent biphasic proarrhythmic and antiarrhythmic effects of quinidine in the presence of 1 nmol/L ATX-II in a female rabbit heart paced at 1 Hz. Monophasic action potentials (top record in each panel) and ECG (bottom record in each panel) were simultaneously recorded. Drug effects recorded during constant pacing at 1 Hz (A–E) and after a 3-second pause (F–J) are shown. Arrowsindicate spontaneous or 3-second pause-triggered episodes of torsade de pointes.

Article Snippet: 11 Twelve-lead ECG recording A 12-lead ECG was recorded using a circular Einthoven-Goldberger ECG electrode system (Harvard Apparatus Inc., Holliston, MA, USA) connected to a Biopac Wilson ECG amplifier (Biopac, Goleta, CA, USA).

Techniques: Concentration Assay